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Paramount Bio Sciences, LLC, a worldwide pharmaceutical development and nicely being care funding agency, was based mostly and managed by Dr. Lindsay A. Rosenwald in 1991. The company facilitates drug development, scientific assist and dedicates itself to discovering and rising novel therapeutic medicines with large potential. By assessing promising drug candidates worldwide, Paramount has been able to create, nurture, and assist higher than 40 life sciences companies, tutorial services, biotechnology and pharmaceutical corporations over the earlier 19 years, along with 20 inside the last 48 months. Current Portfolio Firms have over 40 product candidates advancing by means of medical trials.
Distinctive technique to bio tech funding
Enterprise and product development are merely two gadgets inside the Paramount puzzle. An affiliate of Paramount Bio Sciences – Paramount Bio Capital, Inc., is a FINRA registered broker-dealer that, amongst totally different actions, raises capital for the Paramount Portfolio Firms. It raised over $1 billion for the Portfolio Firms; a lot of events that amount has been raised for Paramount Firms by totally different entities. Whereas enterprise capital and private equity corporations are usually investment-oriented, Paramount’s bias is on the operational facet. It establishes companies from the underside up, using its private capital and at last funds raised from quite a few private and institutional consumers by means of Paramount Bio Sciences and totally different banks and broker-dealers on Wall Highway. Completely, Paramount’s experience in finance and enterprise areas helps make the model attractive to potential licensors and chief authorities officers.
With Paramount Capital largely coping with accounting, financial, market analytical and approved capabilities, managers of its Portfolio Firms can focus largely on driving drug candidates by means of the clinic and creating price for shareholders, licensors and the affected individual group.
Infrastructure and Agency Developing at Paramount
Paramount consists of an in depth assist infrastructure with experience in licensing, medical development, firm operations, and navigating regulatory pathways. Every new portfolio agency at Paramount Bio Sciences is constructed spherical intriguing science and industrial potential. The Portfolio Firms are operated by Paramount Capital by means of a faithful first-class administration on the agency stage, along with by means of enterprise and medical development and operations specialists working for Paramount in New York. Chelsea Therapeutics, as an example, initially was created or based mostly by Dr. Rosenwald spherical a novel anti-folate being developed for the remedy of inflammatory circumstances that included rheumatoid arthritis (RA) and psoriasis. Chelsea’s compound, CH-1504, has demonstrated superiority by means of every safety and efficacy over Methotrexate, the current remedy commonplace for RA, which has been found to lift liver enzymes in plenty of victims. Paramount Capital licensed this experience from the School of South Alabama and assembled a world-class administration group to help optimize its formulation and advance the occasion of this and totally different compounds.
One different tutorial license from Paramount is a portfolio of pure arsenic trioxide compounds licensed from the MD Anderson Most cancers Coronary heart. This FDA permitted compound progressed from IND to NDA in about 30 months and that’s the quickest regulatory approval inside the FDA historic previous. Trisenox, an inorganic numerous of arsenic trioxide, which can product produces cardiac abnor¬malities at extreme doses. Towards this with the inorganic mannequin, pure arsenic trioxide would not current proof of these points, even when used at doses 20 events bigger than Trisenox. To leverage that profit, Dr. Rosenwald based mostly Ziopharm Oncology to advance this pure arsenic compound, ZIO-101, to cope with cancers, along with secure tumors, the place mega dosing has confirmed environment friendly. Ziopharm Oncology, as thought-about considered one of many Paramount’s portfolio companies, subsequently has in-licensed and is rising a lot of totally different anti-cancer brokers.
One different Paramount portfolio agency, based mostly and managed by Lindsay Rosenwald M.D., is Keryx Bio pharmaceuticals. It is rising a compound known as Sulonex, which is an oral treatment for diabetic nephropathy. It was licensed from the Alfa Wassermann Group, a privately held pharmaceutical company in Bologna, Italy. If permitted, Sulonex is perhaps marketed to fifteen million people acknowledged with Type 2 diabetes along with the 1 to 2 million victims with Type 1 diabetes.
